Endocrine Abstracts

Despite significant progress, deficiencies of iron and iodine remain major public health problems affecting >30% of the global population. These deficiencies often coexist in populations. Iron deficiency has adverse effects on thyroid metabolism. Iron deficiency impairs thyroid hormone synthesis by reducing activity of heme-dependent thyroid peroxidase. Iron-deficiency anemia blunts, and iron supplementation improves the efficacy of iodine supplementation. Studies have dem...

A positive expression of oestrogen-receptors has recently been demonstrated in pancreatic neuroendocrine tumours as well as in non-neoplastic islet-cells. This prompted us to systematically analyse the expression of both oestrogen and progesterone receptors in a series of GEP neuroendocrine tumours. We analysed oestrogen- and progesterone-receptor in 69 foregut GEP, 25 midgut GEP and seven hindgut GEP. Namely, the foregut GEP included 53 pancreatic NET. All tumour samples were...

Objective: It is still unknown how pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. Definition of adenoma growth kinetics would substantially enhance knowledge of biological behaviour. The objective of this study was to define a growth model for non-functioning pituitary adenomas.Methods: Fifteen patients who had five or more serial high-quality examinations with magnetic resonance images or computerized tomo...

Purpose: Thyrotoxic patients have an increased bone turnover and decreased Bone Mineral Density (BMD) at diagnosis. During antithyroid drug treatment (ATD) the patients improved their BMD but earlier studies have not been able to determine if BMD normalize or how long it will take.Methods: We have prospectively examined 32 females (approved by Danish Ethical Committee) with newly diagnosed Graves’ disease (antilog10, mean age (CI 95%)): 39 years (34...

Background: Classic 21-hydroxylase deficiency (21HD) presents some traits of the metabolic syndrome. We aimed to characterize discrete alterations of lipid and carbohydrate metabolism in children and young adults with classic 21HD, which could predict early atherogenesis.Design: Cross-sectional comparative.Patients and methods: Of 27 Caucasian patients with classic 21HD (4–31 years); 27 sex-, age- and BMI-matched controls. Cli...

Preliminary data from the French SAGhE study of 6928 pts with isolated idiopathic GH deficiency (IsIGHD), idiopathic short stature (ISS) or born small for gestational age (SGA) who started GH treatment during childhood (1985–1996) & were followed up in 2009, suggested increased mortality vs the French general population (pop; standardized mortality ratio (SMR): 1.3, 95% confidence interval (CI): 1.1–1.6; 116 403 person-years (PY))1.<p class="abstex...

Preliminary data suggested an increased mortality in a French cohort after childhood somatropin treatment compared to the French reference population1. This cohort included patients (pts) with idiopathic-isolated GH-deficiency (GHD), and a similar cohort is also under follow-up for adult GH-replacement in HypoCCS.We therefore assessed all-cause mortality rates (n/1000 person-years (PY), (95% CI), standardized to the age/gender structure...

Patients originally diagnosed with IsGHD may develop additional pituitary hormone deficiencies later in life. This study aimed to identify factors that predict development of MPHD and to characterize the time course of specific hormone deficiencies. Pediatric patients with IsGHD were from an observational study (GeNeSIS). Additional hormone deficiency during follow-up was accepted, if indicated by check box on the case report forms, by an adverse event or by starting replaceme...

The survival of the semiallogeneic fetus within the mother is thought to be due to mechanisms of immunological tolerance. Regulatory T cells (Treg) are believed to have a crucial role in maintaining pregnancy by creating a transient tolerant microenvironment within the maternal uterus as former studies confirmed. We have evidences that Treg expand in lymph nodes from normal pregnant mice already on day 2 of pregnancy. Abortion-prone mice present diminished numbers of Treg in i...

Congenital adrenal hyperplasia (CAH) comprises autosomal recessive disorders mainly due to defects in the 21-hydroxylase (CYP21) gene. We aimed to perform a genotype-phenotype analysis in Romanian patients with classical 21-hydroxylase deficiency.Patients and methods: We included 42 patients (13 males, 29 females, 19 with the salt wasting (SW) form, 29 with the simple virilizing (SV) form. Molecular analysis was performed by direct sequencing of PCR ampl...